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Neuroendocrine Small Cell Carcinoma of the Bladder: Rare and Aggressive Entity

Author(s): M. Rkik, M. Modeste, A. Ettanji, A. Kbiro, M. Dakir, A. Debbaghi

Neuroendocrine small cell carcinoma of the bladder is a rare cancer, rapidly aggressive and metastatic with a very pejorative behavior. The diagnosis is based on histological analysis coupled with immunohistochemical study. Because it is rare, there is no consensus to date. Its management should be multidisciplinary, involving surgery, chemotherapy, and radiotherapy. We report two new cases of neuroendocrine small cell carcinoma of the bladder, one is pure and the other associated with urothelial carcinoma. The poor outcome illustrates the quick evolution of this tumor. A review of the literature on this topic is also presented.

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