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Prognostic Analysis of Patients with Resectable T4 Colorectal Cancer

Author(s): Wei Chen, Xiao-ping Tan, Jun-Wen Ye, Yan Zhang, Jing-Lin Liang, Mei-Jin Huang

Background: To observe the factors related to the survival and prognosis of patients with resectable stage T4 colorectal cancer.

Methods: A total of 148 patients with resectable stage T4 colorectal cancer who underwent surgery at the First Affiliated Hospital of Sun Yat-sen University between August, 1994 and December, 2005 were retrospectively analysed. Univariate and multivariate analyses of the associations between clinicopathological variables and survival were analysed using the Cox regression model.

Results: The follow-up period ended in December 2010 or at patient death; the 5-year and 10-year overall survival (OS) rates were 49.0% and 32.2%, respectively, and the median OS duration was 25 months. The 5-year and 10-year disease-free survival (DFS) rates were 44.2% and 30. 3%, respectively. In univariate analysis, postoperative pathology indicating lymph node metastasis was associated with patient prognosis in terms of OS (all P< 0.01), and postoperative adjuvant therapy failed to improve OS or DFS (P>0.05). Postoperative pathology indicating lymph node metastasis was also associated with DFS (all P< 0.01). In multivariate analysis, postoperative pathology indicating lymph node metastasis was an independent factor affecting OS and DFS in colorectal cancer patients.

Conclusion: The postoperative prognosis of T4 colorectal cancer patients is poor, and postoperative pathology indicating lymph node positivity was an independent factor for OS and DFS.

 

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