Success of Controlled Ovarian Hyperstimulation and Intrauterine Insemination in couple with Unexplained Infertility

Author(s): Nazdar Raouf, Roj Hikmat, Aveen Munib, Maida Shamdeen, Ramadhan Salahaldeen, Hameed Abdullah

Background: Management of unexplained infertility remains largely empirical, the therapeutic approach should be individualized taking into account patient age and duration of infertility, treatments include expectant observation with timed intercourse and lifestyle changes, controlled ovarian hyperstimulation with intrauterine insemination, and in vitro fertilization. The aim of this study was to assess the pregnancy rate and outcome of couples with unexplained infertility treated with intrauterine insemination after controlled ovarian hyperstimulation and to evaluate the effect of various prognostic factors.

Results: In this study 198 cycles of controlled ovarian stimulated intrauterine insemination were analyzed for 110 couples with unexplained infertility. The overall pregnancy rate in our study was 30.9%.

Conclusion: Ovarian stimulation combined with intrauterine insemination is a cost-effective treatment for couple with unexplained infertility before jumping into in vitro fertilization, but recommend that couples be informed of all information about the chances of success as well as the costs and complications of this treatment.