Biography

Chenlu Liu published latest article in Histology and histopathology entitled Protective effects of the pericellular matrix of chondrocyte on articular cartilage against the development of osteoarthritis. This article is available in PubMed with an unique identification number PMID: 29359311 and it is published in 2018. The coauthors of this article are Liu C, Wang B, Xiao L, Li Y, Xu L, Zhao Z, Zhang L.


Research Interest

Dental Research


Latest Publication Details

Article Title: Protective effects of the pericellular matrix of chondrocyte on articular cartilage against the development of osteoarthritis.

Co-Author(s): Liu, C; Wang, B; Xiao, L; Li, Y; Xu, L; Zhao, Z; Zhang, L

Affiliation(s): Laboratory of Molecular and Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education at Sichuan University, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.

PMID 29359311, Year 2018

Abstract: Understanding the pathogenesis of osteoarthritis (OA) provides invaluable information in the search of therapeutic targets for the development of disease-modifying OA drugs. Emerging results from investigations demonstrate that the pericellular matrix of chondrocytes plays important roles in protecting articular cartilages from being degraded. Thus, maintaining the structural integrity of the pericellular matrix may be an effective approach to prevent the development of osteoarthritic joints. In this review article, we discuss the consequences of lacking one or more components of the pericellular matrix, and biological effects of the destruction of the pericellular matrix in the development of OA. We believe that more attention should be directed towards the pericellular matrix for the identification of novel biomarkers and therapeutic targets for the prevention and treatment of OA.

Journal: Histology and histopathology

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