Jennifer C Stearns published latest article in Genome medicine entitled Ethnic and diet-related differences in the healthy infant microbiome. This article is available in PubMed with an unique identification number PMID: 28356137 and it is published in 2017. The coauthors of this article are Stearns JC, Zulyniak MA, de Souza RJ, Campbell NC, Fontes M, Shaikh M, Sears MR, Becker AB, Mandhane PJ, Subbarao P, Turvey SE, Gupta M, Beyene J, Surette MG, Anand SS, .

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Article Title: Ethnic and diet-related differences in the healthy infant microbiome.

Co-Author(s): Stearns, JC; Zulyniak, MA; de Souza, RJ; Campbell, NC; Fontes, M; Shaikh, M; Sears, MR; Becker, AB; Mandhane, PJ; Subbarao, P; Turvey, SE; Gupta, M; Beyene, J; Surette, MG; Anand, SS; ,

Affiliation(s): Department of Medicine, McMaster University, Hamilton, ON, Canada.

PMID 28356137, Year 2017

Abstract: The infant gut is rapidly colonized by microorganisms soon after birth, and the composition of the microbiota is dynamic in the first year of life. Although a stable microbiome may not be established until 1 to 3?years after birth, the infant gut microbiota appears to be an important predictor of health outcomes in later life.We obtained stool at one year of age from 173 white Caucasian and 182 South Asian infants from two Canadian birth cohorts to gain insight into how maternal and early infancy exposures influence the development of the gut microbiota. We investigated whether the infant gut microbiota differed by ethnicity (referring to groups of people who have certain racial, cultural, religious, or other traits in common) and by breastfeeding status, while accounting for variations in maternal and infant exposures (such as maternal antibiotic use, gestational diabetes, vegetarianism, infant milk diet, time of introduction of solid food, infant birth weight, and weight gain in the first year).We demonstrate that ethnicity and infant feeding practices independently influence the infant gut microbiome at 1?year, and that ethnic differences can be mapped to alpha diversity as well as a higher abundance of lactic acid bacteria in South Asians and a higher abundance of genera within the order Clostridiales in white Caucasians.The infant gut microbiome is influenced by ethnicity and breastfeeding in the first year of life. Ethnic differences in the gut microbiome may reflect maternal/infant dietary differences and whether these differences are associated with future cardiometabolic outcomes can only be determined after prospective follow-up.

Journal: Genome medicine

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