Kyungsup Shin published latest article in Tissue engineering. Part A entitled Biomimetic Mineralization of Biomaterials Using Simulated Body Fluids for Bone Tissue Engineering and Regenerative Medicine. This article is available in PubMed with an unique identification number PMID: 28463603 and it is published in 2017. The coauthors of this article are Shin K, Acri T, Geary S, Salem AK.
Co-Author(s): Shin, K; Acri, T; Geary, S; Salem, AK
Affiliation(s): 1 Department of Orthodontics, College of Dentistry and Dental Clinics, University of Iowa , Iowa City, Iowa.
PMID 28463603, Year 2017
Abstract: Development of synthetic biomaterials imbued with inorganic and organic characteristics of natural bone that are capable of promoting effective bone tissue regeneration is an ongoing goal of regenerative medicine. Calcium phosphate (CaP) has been predominantly utilized to mimic the inorganic components of bone, such as calcium hydroxyapatite, due to its intrinsic bioactivity and osteoconductivity. CaP-based materials can be further engineered to promote osteoinductivity through the incorporation of osteogenic biomolecules. In this study, we briefly describe the microstructure and the process of natural bone mineralization and introduce various methods for coating CaP onto biomaterial surfaces. In particular, we summarize the advantages and current progress of biomimetic surface-mineralizing processes using simulated body fluids for coating bone-like carbonated apatite onto various material surfaces such as metals, ceramics, and polymers. The osteoinductive effects of integrating biomolecules such as proteins, growth factors, and genes into the mineral coatings are also discussed.
Journal: Tissue engineering. Part A