Warwick J Duncan published latest article in Journal of biomedical materials research. Part B Applied biomaterials entitled Wool-derived keratin hydrogel enhances implant osseointegration in cancellous bone. This article is available in PubMed with an unique identification number PMID: 29226584 and it is published in 2017. The coauthors of this article are Duncan WJ, Greer PFC, Lee MH, Loch C, Gay JHA.

Research Interest

Dental Research

Latest Publication Details

Article Title: Wool-derived keratin hydrogel enhances implant osseointegration in cancellous bone.

Co-Author(s): Duncan, WJ; Greer, PFC; Lee, MH; Loch, C; Gay, JHA

Affiliation(s): Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, 9054, New Zealand.

PMID 29226584, Year 2017

Abstract: This study investigated whether a keratin hydrogel derived from wool enhances ossointegration of dental implants, using a cancellous bone model in sheep.Ten female sheep received one dental implant per hind leg in the distal femoral condyles. Test implants were coated with 1 mL of keratin hydrogel containing sulphonated keratin and hydroxyapatite; control implants remained uncoated; implants were not functionally loaded axially. Biomechanical stability was tested with resonance frequency analysis (RFA) at placement and euthanasia. Animals were sacrificed after 4 weeks and resin-embedded histomorphometry performed.Bone appeared denser and more mature around the keratin-treated test implants. Average % bone-implant contact was significantly increased for the test (58.1???4.6 [SD]%) compared to control implants (34.4???7.5%) (p?=?0.01). RFA values were lower for control (76.5???4.2 ISQ) than test implants (80.4???1.4) after 4 weeks (p?=?0.04).the increase in osseointegration found in this model suggests that keratin hydrogel has the potential to enhance the successful osseointegration of dental implants placed into poor quality bone. ? 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2017.

Journal: Journal of biomedical materials research. Part B, Applied biomaterials

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