Warwick J Duncan published latest article in Journal of biomedical materials research. Part B Applied biomaterials entitled Wool-derived keratin hydrogel enhances implant osseointegration in cancellous bone. This article is available in PubMed with an unique identification number PMID: 29226584 and it is published in 2017. The coauthors of this article are Duncan WJ, Greer PFC, Lee MH, Loch C, Gay JHA.
Co-Author(s): Duncan, WJ; Greer, PFC; Lee, MH; Loch, C; Gay, JHA
Affiliation(s): Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, 9054, New Zealand.
PMID 29226584, Year 2017
Abstract: This study investigated whether a keratin hydrogel derived from wool enhances ossointegration of dental implants, using a cancellous bone model in sheep.Ten female sheep received one dental implant per hind leg in the distal femoral condyles. Test implants were coated with 1 mL of keratin hydrogel containing sulphonated keratin and hydroxyapatite; control implants remained uncoated; implants were not functionally loaded axially. Biomechanical stability was tested with resonance frequency analysis (RFA) at placement and euthanasia. Animals were sacrificed after 4 weeks and resin-embedded histomorphometry performed.Bone appeared denser and more mature around the keratin-treated test implants. Average % bone-implant contact was significantly increased for the test (58.1???4.6 [SD]%) compared to control implants (34.4???7.5%) (p?=?0.01). RFA values were lower for control (76.5???4.2 ISQ) than test implants (80.4???1.4) after 4 weeks (p?=?0.04).the increase in osseointegration found in this model suggests that keratin hydrogel has the potential to enhance the successful osseointegration of dental implants placed into poor quality bone. ? 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2017.
Journal: Journal of biomedical materials research. Part B, Applied biomaterials