Biography

Wei Seong Toh published latest article in Seminars in cell & developmental biology entitled MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment. This article is available in PubMed with an unique identification number PMID: 27871993 and it is published in 2017. The coauthors of this article are Toh WS, Lai RC, Hui JHP, Lim SK.


Research Interest

Dental Research


Latest Publication Details

Article Title: MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment.

Co-Author(s): Toh, WS; Lai, RC; Hui, JHP; Lim, SK

Affiliation(s): Faculty of Dentistry, National University of Singapore, Singapore; Tissue Engineering Program, Life Sciences Institute National University of Singapore, Singapore. Electronic address: dentohws@nus.edu.sg.

PMID 27871993, Year 2017

Abstract: Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in cartilage repair in animal and clinical studies. The efficacy of MSC-based therapies which was previously predicated on the chondrogenic potential of MSC is increasingly attributed to the paracrine secretion, particularly exosomes. Exosomes are thought to function primarily as intercellular communication vehicles to transfer bioactive lipids, nucleic acids (mRNAs and microRNAs) and proteins between cells to elicit biological responses in recipient cells. For MSC exosomes, many of these biological responses translated to a therapeutic outcome in injured or diseased cells. Here, we review the current understanding of MSC exosomes, discuss the possible mechanisms of action in cartilage repair within the context of the widely reported immunomodulatory and regenerative potency of MSC exosomes, and provide new perspectives for development of an off-the-shelf and cell-free MSC therapy for treatment of cartilage injuries and osteoarthritis.

Journal: Seminars in cell & developmental biology

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