Biography

Saif Afat published latest article in Journal of neuroradiology. Journal de neuroradiologie entitled Diagnostic performance of different perfusion algorithms for the detection of angiographical spasm. This article is available in PubMed with an unique identification number PMID: 29412162 and it is published in 2018. The coauthors of this article are Afat S, Brockmann C, Nikoubashman O, M?ller M, Thierfelder KM, Kunz WG, Haberland U, Brockmann MA, Nikolaou K, Wiesmann M, Othman AE.


Research Interest

Healthcare


Latest Publication Details

Article Title: Diagnostic performance of different perfusion algorithms for the detection of angiographical spasm.

Co-Author(s): Afat S, Brockmann C, Nikoubashman O, M?ller M, Thierfelder KM, Kunz WG, Haberland U, Brockmann MA, Nikolaou K, Wiesmann M, Othman AE

Affiliation(s): Department of Diagnostic and Interventional Neuroradiology, RWTH Aachen University, 52074 Aachen, Germany.

PMID 29412162, Year 2018

Abstract: To assess the diagnostic utility of different perfusion algorithms for the detection of angiographical terial spasm.During a 2-year period, 45 datasets from 29 patients (54.2?10,75y, 20F) with suspected cerebral vasospasm after aneurysmal subarachnoid hemorrhage were included. Volume Perfusion CT (VPCT), Non-enhanced CT (NCT) and angiography were performed within 6hours post-ictus. Perfusion maps were generated using a maximum slope (MS) and a deconvolution-based approach (DC). Two blinded neuroradiologists independently evaluated MS and DC maps regarding vasospasm-related perfusion impairment on a 3-point Likert-scale (0=no impairment, 1=impairment affecting <50%, 2=impairment affecting >50% of vascular territory). A third independent neuroradiologist assessed angiography for presence and severity of arterial narrowing on a 3-point Likert scale (0=no narrowing, 1=narrowing affecting <50%, 2=narrowing affecting>50% of artery diameter). MS and DC perfusion maps were evaluated regarding diagnostic accuracy for angiographical arterial spasm with angiography as reference standard. Correlation analysis of angiography findings with both MS and DC perfusion maps was additionally performed. Furthermor, the agreement between MS and DC and inter-reader agreement was assessed.DC maps yielded significantly higher diagnostic accuracy than MS perfusion maps (DC:AUC=.870; MS:AUC=.805; P=0.007) with higher sensitivity for DC compared to MS (DC:sensitivity=.758; MS:sensitivity=.625). DC maps revealed stronger correlation with angiography than MS (DC: R=.788; MS: R=694;=<0.001). MS and DC showed substantial agreement (Kappa=.626). Regarding inter-reader analysis, (almost) perfect inter-reader agreement was observed for both MS and DC maps (Kappa?981).DC yields significantly higher diagnostic accuracy for the detection of angiographic arterial spasm and higher correlation with angiographic findings compared to MS.

Journal: Journal of neuroradiology. Journal de neuroradiologie

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