Biography

Chhavarath Dary published latest article in Natural product research entitled Chemical profiling of the tuber of Stephania cambodica Gagnep. (Menispermaceae) and analytical control by UHPLC-DAD. This article is available in PubMed with an unique identification number PMID: 27976592 and it is published in 2017. The coauthors of this article are Dary C; Bun SS; Herbette G; Mabrouki F; Bun H; Kim S; Jabbour F; Hul S; Baghdikian B; Ollivier E.


Research Interest

Pharmacy


Latest Publication Details

Article Title: Chemical profiling of the tuber of Stephania cambodica Gagnep. (Menispermaceae) and analytical control by UHPLC-DAD.

Co-Author(s): Dary C; Bun SS; Herbette G; Mabrouki F; Bun H; Kim S; Jabbour F; Hul S; Baghdikian B; Ollivier E

Affiliation(s): a Laboratory of Pharmacognosy and Ethnopharmacology, Faculty of Pharmacy , Aix Marseille Univ, UMR-MD3 , Marseille , France.

PMID 27976592, Year 2017

Abstract: A new aporphine glycoside (1), named angkorwatine, and eight known alkaloids: oblongine (2), stepharine (3), asimilobine-?-d-glucopyranoside (4), isocorydine (5), tetrahydropalmatine (THP) (6), jatrorrhizine (7), palmatine (PAL) (8), and roemerine (ROE) (9) were simultaneously isolated from the tuber of Stephania cambodica. The development and validation of UHPLC-DAD method was carried out for the quantification of marker compounds (PAL, ROE, THP) of S. cambodica. In addition to good selectivity and linearity (r2 > 0.997), trueness, precision, and accuracy of the method did not exceed the acceptance limit of ±10% for ROE, THP and ±20% for PAL. Consequently, this method is able to provide accurate results between 1.39-4.18 ?g/mL, 2.01-30.72 ?g/mL, and 4.29-64.42 ?g/mL for PAL, ROE, and THP, respectively. This study shows that the validated UHPLC method is a rapid, innovative and effective analytical approach to control quality of tubers of S. cambodica and to regulate the usage of this plant in traditional medicine.

Journal: Natural product research

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