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Acute and Maintenance Efficacy of Deep TMS in Depression with Mixed Features

Author(s): Jean-Michel Azorin, Christophe Gouraud RN, Léa Guintrand RN

Background: There is evidence that repetitive transcranial magnetic stimulation (rTMS) is efficacious against depression in bipolar disorder but there are less data for mania. Similarly it has been suggested that rTMS may be effective against depressive symptoms in mixed states, with fewer evidence regarding manic symptoms. Deep TMS (dTMS) has been reported to be efficacious in bipolar depression, but there are no data concerning mixed states.

Procedure: We report the case of a bipolar II patient, in which dTMS displayed acute and maintenance efficacy against the depressive and hypomanic symptoms of a depressive episode with mixed features.

Conclusion: Randomized-controlled studies should be conducted to assess the acute and maintenance efficacy of dTMS in depression with mixed features.

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    Michael Maes

  • Molecular Biology and Neuroscience
    Deakin University
    Victoria, Australia

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