Association of Interleukin-10 with Severity of Axial Spondyloarthritis in Patients Attending in A Tertiary Care Hospital in Dhaka City

Author(s): Raisa Enayet Badhan, Ahmed Abu Saleh, Shaheda Anwar

Objective: The aim of the study was to determine the association of interleukin-10 (IL-10) level with severity of axial spondyloarthritis (axSpA).

Materials and methods: According to Assessment of Spondyloarthritis International Society (ASAS) criteria, 38 patients with axSpA (clinically diagnosed by Rheumatologist, attending outpatient department of Rheumatology, Bangabandhu Sheikh Mujib Medical University, BSMMU) and 38 healthy controls (resident doctors, laboratory staffs of BSMMU and general people) were enrolled. Blood samples were collected after taking informed written consent and data in a predesigned data collection sheet. Serum IL-10 levels were measured by Enzyme Linked Immunosorbent Assay (ELISA) at Microbiology and Immunology Department, BSMMU.

Results: Among 38 patients, 63.2% were male. According to Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), 14 patients were in mild to moderate group and 24 in severe group. Serum level of IL-10 were significantly higher in patients compared to controls (3.69 pg/ml vs 0.88 pg/ml, P<0.001). Mean IL-10 levels in inactive disease group were comparatively higher than active disease group (P<0.001).

Conclusion: Serum level of IL-10 is significantly elevated in axSpA patients and is negatively correlated with disease activity.