Correlation of Clinical Characteristics and Selective Biochemical Marker in Adolescent PCOS

Author(s): Nur-E-Nazma

Background:

It is fundamental to comprehend the incidence of polycystic ovarian syndrome (PCOS) worldwide because geographic and ethnic variations might significantly affect the clinical state. This study aims to measure the correlation between clinical characteristics and specific biochemical markers in adolescents with PCOS.

Methods:

A cross-sectional study was conducted in the Department of Obstetrics & Gynaecology, Institute of Child and Mother Health, Matuail, Dhaka, from January 2015 to December 2015. Ninety-five suspected cases of adolescent PCOS patients were selected using purposive sampling.

Results:

More than one-third (35.8%) of the patients belonged to the age group of 17-18 years; most of them were unmarried (92.6%) with normal BMI (52.6%). Among them, 70.5% had oligomenorrhoea, and 40% had hirsutism; the mean value of FSH, LH, and testosterone was 4.04±1.42, 9.92±5.57 (IU/liter), and 1.92±0.48 (nmol/L) respectively. About 65% of adolescents had normal fasting glucose/insulin ratio, but insulin resistance was found in 35% of the participants. Serum FSH was not significant (p=0.756) among the categories of menstrual abnormality, but serum LH (P=0.010) and LH/FSH ratios (P=0.014) had significant association among the patients with amenorrhoea and oligomenorrhoea. FSH 0.756, LH 0.010* LH/FSH 0.014*

Conclusion:

The study found that adolescents' serum LH and LH/FSH ratios were significantly higher with amenorrhoea and oligomenorrhoea. Among the participants, no statistically significant difference was noted in fasting insulin levels. However, the fasting glucose/insulin ratio was higher in individuals with neuropathic hemorrhagic compared to those with amenorrhea and oligomenorrhea.