Median Lethality Dose of Xylopia aethiopica Fruit Ethanol Extract

Author(s): Akinloye OA, Ayodele PF, Ore A

The present study was designed to assess the median lethality dose of Xylopia aethiopica fruit ethanol extract (XAFEE) administration on sixteen albino rats. The animals were assigned to four groups (n=4). Each group was administered orally as single arithmetic doses of 1000 mg/kg b.w, 2000 mg/kg b.w, 3000 mg/kg b.w and 4000 mg/kg b.w respectively. The animals were monitored and examined for about 24 h, thereafter, for mortality after the extract administration. Maximum dose with 0% and minimum dose with 100% mortality were recorded as 3000 mg/kg b.w and 4000 mg/kg b.w. Thus, the median lethality dose (LD50) is 3,464 mg/kgb.w.