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Intraoperative Cone Beam CT in Hybrid Operating Room Set-Up as an Alternative to Postoperative CT for Pedicle Screw Breach Detection

Article Information

Simon Peh1, Julian Pfarr2, Mathis Wegner1*, Jost Philipp Schäfer2, Jan-Hendrik Christensen1, Anindita Chatterjae3, Rami Nachabe3, Andreas Seekamp1, Sebastian Lippross1

1Department of Orthopedics and Trauma Surgery, University Hospital Schleswig-Holstein, Arnold-Heller-Strasse 3, Germany

2Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Arnold-Heller-Strasse 3, Germany

3Image Guided Therapy Systems, Philips Healthcare, Veenpluis 4-6, The Netherlands

*Corresponding Author: Dr. Mathis Wegner, Department of Orthopedics and Trauma Surgery, University Hospital Schleswig-Holstein, Arnold-Heller-Strasse 3, 24105 Kiel, Germany

Received: 02 March 2022; Accepted: 09 March 2022; Published: 18 March 2022


Simon Peh, Julian Pfarr, Mathis Wegner, Jost Philipp Schäfer, Jan-Hendrik Christensen, Anindita Chatterjae, Rami Nachabe, Andreas Seekamp, Sebastian Lippross. Intraoperative Cone Beam CT in Hybrid Operating Room Set-Up as an Alternative to Postoperative CT for Pedicle Screw Breach Detection. Journal of Spine Research and Surgery 4 (2022): 040-053.

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Background: CT is considered the gold standard for detecting pedicle breach. However, CBCT may be a viable and low radiation dose alternative to provide intraoperative feedback to surgeons to permit in-room revisions of misplaced screws.

Methods: To assess the ability and reliability of intraoperative cone-beam CT (CBCT) from a robotic C-arm in a hybrid operating room (OR) two hundred forty-one pedicle screws were inserted in cervical, thoracic and lumbar spine of 7 cadavers followed by CBCT and CT imaging. The CT images served as the standard of reference. Agreement on screw placement between both imaging systems was assessed using Cohen’s Kappa coefficient (κ). Sensitivity, specificity, receiver operating characteristic (ROC), area under the empirical and fitted ROC curves (AUC) were computed to assess CBCT as a diagnostic tool compared to CT. The patient effective radiation dose (ED) was calculated for comparison. A systematic literature review was performed to provide perspective to the obtained results.

Results: Almost perfect agreement in assessing pedicle screw grading between CBCT and CT was observed (κ=0.84). The sensitivity and specificity of CBCT were 0.84 and 0.98 respectively. The AUC derived from the empirical and fitted ROC curves were 0.95 and 0.96.

Conclusion: Intraoperative CBCT by C-arm in a hybrid OR is highly reliable in identification of screw placement at significant dose reduction.


Hybrid Operating Room, Cone Beam Computed Tomography, Pedicle Screw Placement, Pedicle Breach, Minimally Invasive Spine Surgery, Dose Reduction

Hybrid Operating Room articles; Cone Beam Computed Tomography articles; Pedicle Screw Placement articles; Pedicle Breach articles; Minimally Invasive Spine Surgery articles; Dose Reduction articles

Article Details

1. Introduction

Accurately positioned pedicle screws offer optimal biomechanical fixation, making them a well-accepted treatment choice for a variety of spine pathologies [1, 2]. However, up to 42% of pedicle screws were reported to be malpositioned [3, 4]. While initially clinically silent, these may eventually result in an unstable construct, reduced fusion, pseudoarthrosis and accelerated adjacent-level degeneration [5]. In comparison to CT, radiography detects only 52% of misplaced screws [6, 7], making intraoperative CT imaging necessary for complex deformity, to avoid revision surgeries. Availability of intraoperative 3D imaging resulted in revision of 9% of screws intra-operatively corresponding to 35% of the treated patients. Lower threshold for intraoperative revisions based on objective intraoperatively available imaging data, leads to fewer secondary revision surgeries [8]. Avoidance of postoperative revisions makes the initial investment in intraoperative 3D imaging tech-nologies economically more attractive [9]. Hybrid operating rooms (OR) equipped with a motorized C-arm coupled with a radiolucent surgical table as well as with integrated navigation capabilities, have been recently used for spine surgery [10]. The C-arm provides intraoperative cone-beam CT (CBCT) imaging. The purpose of this cadaver study was to determine the diagnostic performance of intrao-perative CBCT using a C-arm in a hybrid OR for identifying screw misplacements in comparison to gold-standard postoperative CT. To put our results in perspective, a sytematic literature review of studies comparing intraoperative 3D imaging for screw misplacements with postoperative CT was conducted.

2. Materials and Methods

2.1 Surgical technique

Surgeries were performed by one surgeon in a hybrid

OR (AlluraClarity Flexmove, Philips, the Nether-lands), Figure 1. Cadavers were placed prone on the operating table, adhesive skin markers were applied and a planning CBCT scan was obtained. Pedicle screw trajectories were planned using Augmented Reality Surgical Navigation system (ARSN, Philips, the Netherlands). Pedicles were instrumented bila-terally from C7 to L5 using tracked Jamshidi needles, aligned along the planned trajectory. Cannulated pedicle screw sizes were 5.5 x 40 mm from C7 to T9; and 6.5 x 45 mm from T10 to L5.

2.2 CBCT imaging: the study group

The C-arm was positioned on the side orthogonal to the operating table along the axial plane of the patient and rolled in this plane to perform CBCT optimized for spine imaging (XperCT Spine, Philips, the Netherlands). The CBCT reconstruction is the result of 302 x-ray projections acquired over a 180-degree clockwise rotation, starting with the x-ray tube on the right side of the table. The acquisition settings were 120 nominal kV tube voltage and modulated tube current-exposure time (mAs) generated by the automatic exposure control which is estimated based on patient size, thickness at each angular projection during the rotation. Radiation dose area products were collected from the radiation dose structured report (RDSR) and converted to patient effective dose (ED). The CBCT reconstruction corresponds to a 512x512x396 matrix with isotropic voxels of 0.49 mm. Consequently, the dimension of the imaged region of interest (ROI) corresponds to a 25x25 cm in the axial plane by 19.5 cm in the cranial-caudal direction [12], Figure 2.

2.3 CT: the reference group

Default settings for spine imaging on a 16-slice CT scanner was used imaging the cadavers (Brillance 16, Philips, the Netherlands). CT image reconstructions were made based on a helical acquisition at 120 kV tube voltage acquisition and a modulated tube current exposure time (mAs) derived from the anterio-posterior and lateral scout scans. Radiation dose length products were collected from the RDSRs and converted to patient ED. The CT image recons-tructions were performed at 0.75 mm slice thickness and dimension of the reconstructed ROI image was 37x37 cm in the axial plane, in cranial-caudal length direction covering the whole instrumented spine, Figure 2.

2.4 Data analysis

The CBCT and CT images were reviewed on a PACS system with 3D volumes displayed in a multi-planar format. The width and level were set to optimize visualization. Screw position assessments were per-formed using the Gertzbein grading [13]:

  1. grade 0 (screw within the pedicle without cortical breach)
  2. grade 1 (0–2 mm breach, minor perforation including cortical encroachment)
  3. grade 2 (2–4 mm breach, moderate breach)
  4. grade 3 (more than 4 mm breach, severe misplacement).

Each screw was assigned a grade from 0 to 3, for each imaging modality. Consequently, a 4x4 cont-ingency table to compare the similarity in rating was created. Figure 3 illustrates an example of each of the 4 grades on both CBCT and CT from the diagonal of the contingency table (i.e. agreement between both imaging modality for each grade). All images in Figure 3 were displayed for comparison at equal display settings optimized for bone and hardware imaging. Grades 0 and 1 were considered clinically accurate, whereas grades 2 and 3 were considered misplaced.

2.5 Statistical analysis

Cohen’s Kappa coefficient (κ) was calculated to assess the agreement between CBCT and CT based on the contingency tables and was classified according to Landis et al. [14] as detailed in Table 1. Sensitivity was defined as the proportion of misplac-ed screws detected on CBCT which were confirmed as such on CT; whereas specificity was defined as the proportion of screws accurately placed according to CBCT which was confirmed as such on CT.

Receiver operating characteristic (ROC) analysis was performed and area under the empirical and fitted ROC curves (AUC) were computed to assess performance of CBCT as a diagnostic tool whose performance was classified according to Hanley et al. [15], Table 1. Two-sided Fisher’s exact and Wilco-xon signed rank tests were used for comparison where appropriate. Two-sided AUC comparison test was performed. Confidence intervals (CI) were computed at 95% and expressed between brackets. A p-value (p) less than 0.05 was considered as significant.

2.6 Literature review

A systematic review was conducted in order to perform a proper comparison with the existing literature on assessing the diagnostic performance of intraoperative 3D imaging versus CT imaging. The review was performed using PubMed Central, PubMed, Embase, Web of Science, and Cochrane with the following search strategy: (“pedicle screw placement” AND “sensitivity” AND “specificity” AND “imaging”). After filtering for duplicates from the various search engines, 5 exclusion criteria were applied during abstract screening: (a) articles not written in English, (b) conference abstracts, (c) articles that do not report about pedicle screw (e.g. sacroiliac screws), (d) articles that are not com-parative studies, and (e) studies that do not consider an intraoperative 3D system as study group (e.g. 2D radiography, electromyography, etc.). After text screening, papers that did not report clinical accuracy for screw placement by using a Gertzbein-like grading i.e. (2-mm increment scale relative to breach) were excluded as also data with inconsistency or missing in-formation. All preclinical and clinical studies were included. Literature data with available contingency tables, or with detailed numbers of screws per grade for each group from which contingency tables could be generated, were used to calculate sensitivity, specificity, and AUC and statistical tests performed to ensure a fair diagnostic performance comparison between all studies.


Figure 1: Set up of the hybrid OR and the patient positioning on the table.


Figure 2: Imaging of the whole spine of one cadaver from the CBCT and CT.


Figure 3: Images displaying all the 4 grades from CBCT and CT for the same screw. The chosen screws for each grade have agreement between both imaging modalities.

Cohen’s Kappa coefficient

Strength of agreement [Ref Landis 1997]

Area under the curve (AUC)

Strength of diagnosis [Ref Hanley 1982]






Almost perfect























Table 1: Relation between Cohen’s Kappa coefficient and strength of intermodality agreement as well as relation between area under the receiver operating characteristic curve value and strength of diagnosis.

3. Results

Two hundred forty-one cannulated pedicle screws were placed percutaneously: 3 (1%), 168 (70%), and 70 (29%) in the cervical, thoracic, and lumbar spine respectively.

3.1 Accuracy comparison between CBCT and CT

All cadavers had their fully instrumented spine imaged with CBCT as seen in comparison with CT, Figure 2. Table 2 corresponds to the contingency table comparing the grading assessment between both imaging modalities for each screw. Out of the 241 placed screws, 134, 22, 6, and 17 screws were rated by both imaging modalities as grade 0, 1, 2, and 3 respectively; yielding a total of 179 screws with equal ratings. With respect to screws considered as accurate placement on CT, twenty-four screws and one screw were rated as grade 1 and 2 respectively on CBCT while they were rated grade 0 on CT, whereas thirteen screws and three screws were rated as grade 0 and 2 respectively on CBCT while they were rated as grade 1 on CT. With respect to screws considered as misplaced on CT, two screws were rated grade 0 and three screws were graded 1 on CBCT while they were rated as grade 2 on CT. Finally, two and twelve screws were rated as grade 1 and 2 on CBCT while they were rated as grade 3 on CT. The Cohen’s Kappa coefficient was κ=0.84 [0.75-0.93] indicating almost perfect agreement in assessing accuracy between CBCT and CT. The agreement in the lumbar spine was almost perfect (κ=0.87 [0.70-1.00]) as well as in the thoracic spine (κ=0.83 [0.59-0.82]). The sensitivity and specificity of CBCT were 0.84 [0.70-0.93] and 0.98 [0.95-0.99] respectively. Sensitivity and specificity in the lumbar spine (0.89 [0.52-1.00] and 0.98 [0.91-1.00]) were higher than in the thoracic spine (0.83 [0.66-0.93] and 0.98 [0.94-1.00]) but not statistically different (p=1 for both). The AUC derived from the empirical and fitted ROC curves were 0.95 [0.91-1.00] and 0.96 [0.92-1.00], respect-tively; indicating CBCT to be an excellent diagnostic tool for pedicle screw placement compared to CT.

3.2 Radiation dose of the subjects

The patient ED in CBCT imaging was significantly lower than CT for all 7 cadavers (median 8.2 mSv vs 12.9 mSv, p<0.05). The average ED was 7.2 ± 5.4 mSv in CBCT vs 14.3 ± 3.4 mSv in CT with a 53% ED reduction on CBCT.

3.3 Literature review and comparison

The initial database search identified 117 studies without any duplicates. 104 articles were excluded after scrutiny of abstracts. The two most common reasons for exclusion were articles not being comparative studies (n=35) and the study group not corresponding to an intraoperative 3D imaging such as 2D radiography, EMG, or other techniques (n=35). Fifteen studies were not related to pedicle screws (e.g. iliac screws), and an equal amount corresponded to conference abstracts. Four abstracts corresponded to papers not written in English. From the remaining 13 articles, 5 other exclusions were applied at text screening level. The most common reason of exclusion was not using a Gertzbein-like grading with 2 mm increment for breach (n=5) [16-20]. One study was excluded because of inconsistency between the data in the abstract and in the text [21]. One study did not use a grading scale but revision surgery as surrogate parameter for screw misplace-ment [22]. Another study did not confirm whether the obtained accuracy was indeed breach <2mm or all breaches (i.e. grades 1, 2 and 3) [23]. One study did not provide enough information to compute accuracy for breach <2mm and considered all breaches as misplaced screws [24]. Finally, there were 4 studies that were discussed in this review [25-28], Figure 4. Two cadaveric studies compared intraoperative CBCT vs macroscopic dissection [25, 26]. In one study results were compared to CT as well [26]. Two clinical studies compared CBCT vs CT [27, 28]. Details are presented in Table 3, showing sensitivity, specificity, and AUC where applicable. Sensitivity and specificity in literature ranged between 0.69-0.86 and between 0.71-1.00, respectively. The AUC could only be derived from one study [28] with an available contingency table yielding an AUC from the empirical and fitted ROC curves of 0.91 [0.83-0.98] and 0.93 [0.87-1.00] respectively. Figure 5 shows a comparison of the ROC curves and corresponding AUC.


Figure 4: Strategy and inclusion/exclusion criteria for the literature search review.


Grade 0

Grade 1

Grade 2

Grade 3


Grade 0





Grade 1





Grade 2





Grade 3





Table 2: Contingency table comparing pedicle screw placement assessment between CBCT and CT.

Table icon

1 C/T/L à cervical/thoracic/lumbar

2 Study by Cordemans et al. reported values for all breaches (ie. Grade 0 vs Grades 1, 2, and 3) with Kappa=0.78 (0.68-0.88), sensitivity=0.77 (0.62-0.88), and specificity=0.98 (0.96-0.99) instead for accuracy (i.e Grades 0 and 1 vs Grades 2 and 3)

CI: confidence interval; K: Kappa

CBCT: cone beam computed tomography; CT computed tomography

Table 3: Literature data comparison. C, T, and L correspond to cervical, thoracic, and lumbar spinal levels, respectively. Κ corresponds to Cohen’s Kappa coefficient. AUCe and AUCf correspond to the area under the empirical and fitted receiver operating characteristic curve, respectively. NA indicates not available data.


Figure 5: Comparison of the ROC curves and the corresponding AUC. (a) Comparison of empirical ROC curves of Cordemans et. al. and this study; (b) Comparison of fitted ROC curves of Cordemans et. al. and this study.

4. Discussion

Hybrid ORs support multidisciplinary use of 2D and 3D imaging and navigation for open and minimal invasive procedures [10]. This cadaver study sought to assess the diagnostic performance of CBCT from a C-arm within a hybrid OR compared to diagnostic CT. Unlike mobile C-arm with CBCT capability and mobile CT, the C-arm system in the hybrid OR has an image acquisition and processing chain com-parable to diagnostic CT scanners. Thus enabling better management of image quality and radiation dose exposure [29]. While macroscopic dissection is the gold reference for evaluating pedicle screw placement, CT is the clinically viable alternative [26]. Choosing a cadaver study over a clinical study allowed for immediate comparison between CBCT and CT. Furthermore, cadaver studies allow uni-formity of CT and CBCT protocols on the same scanner to ensure fair comparisons. In clinical studies, follow-up scans are often performed several months after surgery. Bone remodeling and regrowth or screw loosening occurs during the follow-up period which can influence the Gertzbein grading introducing possibilities for comparison errors.

The almost perfect intermodality agreement of this study was suggestive of CBCT as a viable replace-ment for postoperative CT. The sensitivity obtained for the CBCT images was 0.84, indicating that 84% of misplaced screws detected on CT, were detected on CBCT. Of the 7 screws that were missed as a misplaced screw in CBCT, 6 were in the thoracic region. A specificity of 0.98 indicates, that in 2% of the cases CBCT identified screws as misplaced when they are assessed to be well placed on CT. The screws that had the degree of cortical wall pene-tration overestimated in the CBCT were mainly in the thoracic region. Interestingly 5 of 7 screws were missed as misplaced on CBCT. In 3 of 4 instances the screw was labelled as misplaced on CBCT but was labelled as a well-placed screw on CT. These screws had a difference in position of one grade. In Gertzbein there is an increment of 2mm in the amount of displacement between the consecutive grades. It is likely that the metal artefacts and the small pedicle sizes in the thoracic region, could potentially be the cause for the 2mm error in the assessment. A higher sensitivity compared to speci-ficity suggests that CBCT based assessment tends to underestimate pedicle breaches compared to CT. Clinically, it is important to detect a truly misplaced screw. Therefore, sensitivity is the most important parameter. AUC analysis from ROC curves is the radiologically accepted technique to assess a system’s diagnostic performance described by a single number, as it considers sensitivity and speci-ficity for all grades. The CBCT used in this study yielded AUCs representing an excellent diagnostic tool for assessing screw placement during surgery.

In the conducted systematic literature review 4 studies met the search criteria. The sensitivity and specificity of this study was in the upper range compared to literature, as seen in Table 3. The Cohen’s Kappa and the AUC are indicators for strength of agreement and diagnostic comparisons. The strength of agreement was superior to the study performed with a mobile CBCT by Fujimori et al. [27] and comparable to a study performed with CBCT in a hybrid OR [28]. The study by Cordemans et al. is the only study from which the AUC could be derived for comparison of diagnostic strength [28]. These values were inferior compared to this study but without being a statistical significant difference (p=0.20 and p=0.27 for the empirical and fitted AUC, respectively). The fitted AUC accounts for the continuous nature of measuring breach while the empirical AUC only takes the 2mm increment as defined by Gertzbein. Inclusion of a high number of misplaced screws (18% with a grade 2 or higher breach as per Gertzbein) and screws in the cervical or upper thoracic regions where the pedicle sizes are small (36% screws were in these regions) provide a better evaluation of the technology. This is reflected by the higher confidence interval compared to literature, thereby providing a higher reliability of sensitivity.

The CBCT offers significant patient ED reduction (53% reduction) compared to CT. In institutions where a threshold for patient radiation dose exposure exists for perioperative procedures, there is a justi-fication for using intraoperative CBCT as a diagno-stic tool at a lower radiation dose exposure compared to CT without altering diagnostic judgement of screw placement. Cervical screws were limited in this study and detection of pedicle breach in the cervical region may be more challenging, given the smaller pedicle diameter and the shoulder superimposition in the image. Additional studies addressing other factors impacting image quality such as contrast-to-noise ratio, severity of metal artefacts, image recons-truction algorithm, and radiation dose protocol should be performed to complete the diagnostic evaluation of CBCT versus CT.

5. Conclusions

Intraoperative CBCT by C-arm in a hybrid OR repre-

sents a highly reliable instrument in identifying screw placement at significant dose reduction. A systematic literature search demonstrated superior performance compared to the existing CBCT of mobile C-arm systems confirming reported perfor-mance by another study using a hybrid OR system.

Author Contributions

SP study setup, data acquisition, data analysis, writing. JP Study planning, data acquisition, data analysis. MW manuscript writing, submission. JPS Study planning, data acquisition, data analysis. JHC data analysis, statistics, drafting manuscript. AC Study set-up, data acquisition, data analysis. RN Study setup, data acquisition, data analysis. AS Study planning, manuscript writing. SL Study setup, data acquisition, data analysis, writing. All authors have read and agreed to the published version of the manuscript.


Traveling expenses for the study for Simon Peh and Sebastian Lippross were paid by Philips Healthcare. Rami Nachabe and Anindita Chatterjea are employed by Philips Healthcare, which has a vested interest in the product described in this manuscript. The research has been performed as a part of a research agreement between University Hospital Schleswig-Holstein, Campus Kiel, Germany and Philips Healthcare. For the remaining authors, none were declared beyond this research agreement of their employer.

Institutional Review Board Statement

The study was conducted according to the guidelines of the Declaration of Helsinki. Ethics approval was obtained for a cadaver study from the ethics committee of the Christian-Albrecht-University Kiel, Germany.

Informed Consent Statement

Informed consent was obtained from all subjects involved in the study before decease.

Data Availability Statement

Not applicable

Conflicts of Interest

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.


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