Assessment of C-reactive Protein, Lipid Profile and Body Mass Index in Type2 Diabetes Mellitus in Sudanese Patients

Author(s): Alhussein Alsayed Mukhtar Garrashy, Omer Fudal Idris, Mustafa Salimeen, Ibrahim Eltirafi

Background and aim: Diabetes mellitus (DM) is a disease characterized by chronic hyperglycemia caused by a lack of insulin or resistance, resulting in metabolism dysregulation, which accounts for the symptoms and complications of diabetes. The present study aimed to assess some biochemical markers such as C-reactive protein (CRP), lipid profile, and body mass index (BMI) in type 2 diabetes mellitus (T2DM) in Sudanese patients.

Patients and methods: The study included 104 patients with type two diabetes mellitus (56 men and 48 women, 40 to 70 years old) and 104 non-diabetic healthy volunteers (56 men, 48 women, 40 to 70 years old). Anthropometric measurements were assessed, and blood samples were collected for analysis of lipid profile and C-reactive protein (CRP).

Result: The result showed a significant increase in CRP, BMI, total cholesterol (TC), triglycerides (TGs), non-HDL-C, and LDL-C in the diabetic patients when compared with the healthy control group (P-value 0.000). The study also showed a significant increase in BMI, CRP, TC, non-HDL-C, TGs, and LDL-C in female patients in comparison with male patients with (P-value 0.014, 0.037, 0.003, 0.026, 0.046, and 0.014 respectively). Moreover, the study showed that CRP had a positive correlation with TC, non-HDL-C, TGs, LDL-C, and BMI, with (P-value 0.001, 0.000, 0.000, 0.008, and 0.000 respectively).

Conclusion: The study finally concludes the coexistence of dyslipidemia, overweight, obesity, and inflammation in diabetes, in general, and with more frequent in female diabetes when compared with their male counterparts.