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Covid-19 Infection and its Adverse Effects on Multiorgan

Author(s): Shehnaz Sultana, Samuel Abraham Joshi Davala, Venkateshwari Ananthapur, Penagaluru Pardhanandana Reddy

Covid-19 pandemic, the consequence of severe acute respiratory syndrome (SARS-CoV-2), is one of the main causes of worldwide mortality. The manifestations of SARS-CoV-2 are extensively variable and array from asymptomatic infection to multiorgan failure. The primary mechanism for SARS-CoV-2 infection is the binding of the virus to the membrane bound form of ACE2, which is mostly expressed in the lungs, heart, and kidneys. The presence of comorbidities made patients at a higher risk of developing severe form of Covid-19. Several studies have suggested that SARS-CoV-2 infection have adverse effects on multiorgan. Strategies for proper diagnosis and management of multiorgan effect of Covid-19 have not been established due to the emergence of new variants. However, until more studies are carried out, treatment approaches have to be made on personalized basis depending on the specific organ damage to reduce the overall mortality rate.

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