Visual Evoked Potential Findings of Bardet - Biedl Syndrome

Author(s): Fatemeh Ojani, Seyed Mohammad Masoud Shushtarian, Ahmad Shojaei, Jalil Naghib

Purpose: Bardet – Biedl syndrome (BBS) is a complex disorder that affects many parts of the body including visual pathway of visual system. The purpose of present work is to prove the adverse effects of BBS on visual pathway using visual evoked potentials.

Patients and Methods: Ten patients, 6 males and 4 females with age range of 12 - 20 years were selected. The latency and amplitude of visual evoked potential, P100 peak was recorded for these patients and 10 age and sex matched controls with healthy visual system mainly visual pathway.

Results: The mean age was 15.4 ± 3.06 and 15 ± 2.78 in case and control group respectively. The mean visual acuity in case 0.49 ± 0.14 (LogMAR) and 0 ± 0 (LogMAR) in control group which was statistically significant in two groups which is the characteristics of BBS patients. These was statistically significant higher latency and lower amplitude of visual evoked potential, P100 peak in case group compared control groups (P < 0.001)

Conclusion: BBS have adverse effect on visual system mainly visual pathway causing increased latency and decreased amplitude of VEP, P100 peak measured using visual evoked potential.