Role of Katankateryadi Kwatha in Insulin Secretion and Restoration of Biochemical Changes in Streptozotocin-Nicotinamide Induced Diabetes Mellitus Type 2 in Rats

Author(s): Sanjay Kumar, Minshu Prashant, B. Ram, K. N. Dwivedi

Diabetes Mellitus Type 2 is a metabolic disorder characterized by hyperglycemia with major and minor complications. The major cause of diabetes mellitus type 2 is lack of insulin secretion or insulin resistance. Experimentally the diabetes mellitus type 2 is induced by several chemicals like Streptozotocin (STZ). The nitrosourea moiety of STZ is responsible for producing beta cell toxicity which leads to development of diabetes mellitus type 2 in rats. The experimental study includes the formulation of Katankateryadi Kwatha, characterization of Kwatha, acute oral toxicity study of Kwatha, OGTT and antidiabetic effect of Katankateryadi Kwatha in STZNicotinamide induced diabetes in rats. Diabetic group treated with 200 mg/kg (189.34 ± 3.89 mg/dL FBG). Post prandial blood glucose (PPBG) level in Diabetic group treated with 200 mg/kg of Katankateryadi Kwatha shows better reduction in PPBG 159.35 ± 6.29 mg/dL in comparison to diabetic rats treated with 100 mg/kg (180.34 ± 2.45 mg/dL). Rats treated with 200 mg/kg Katankateryadi Kwatha significantly reduced the SGOT and SGPT level (133.34±2.25 IU/L and 170.89±3.76 IU/L). The group treated with Katankateryadi Kwatha (200 mg/kg) treated group increased the HDL level (23.56 ± 5.23) and decreases the TC (112.56 ± 3.24), TG (71.65 ± 5.26), LDL (52.41 ± 2.11) and VLDL (21.05 ± 4.62). C-Peptide data result shows that C-Peptide decreased in diabetic rats 0.36 ± 0.034 ng/dl. Katankateryadi Kwatha is useful in management of diabetes mellitus type 2.