Biological Evaluation and Anticancer Activity of Novel Binary Transition Metal Complexes Derived from Ortho Amino Benzo Hydroxamic Acid

Author(s): D. Anitha Ranga Sree

Cobalt, Nickel, Copper, Zinc acetate salts are reacted with Ortho-amino benzo hydroxamic acid (OABH) in ethanol generate tetra co-ordinate complexes with the formula [M (II) (OABH) (H2O)] called as binary metal complex. Characterization of binary metal complexes are further calculated by IR, UV-VIS, ESR, microanalysis, molar conductance, magnetic susceptibility, mass spectra, and thermogravimetric analysis (TGA).M (II) being co-ordinate by tri- dentate OABH ligand and complexes are found to be mononuclear where it is checked by experimental data through enolic oxygen, amino, and the azomethine nitrogen atoms. Spectral data of UV-Vis and magnetic susceptibility have recommended the novel metal complexes show square planar and tetrahedral geometry. Complexes are tested for their abilities in biological activity. Antimicrobial tests of the ligand and novel binary complexes have been carried out. The outcome was evaluated with some well-known antibiotics. Synthesized metal complexes are appraised for the anticancer activity in cancer cells of A549 (lung cancer, CCL-185), SKNSH (Human neuroblastoma cancer, CCL-131), and Hela (cervical cancer, CCL-2) gives much more promising candidates to aim further structure activity-based studies.