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Atrial Fibrillation Screening in Elderly Patients With Risk Factors for Stroke. The Value of Prolonged Cardiac Monitoring

Article Information

Mariana Alves1*, André Rodrigues1, Fabrizio Cossutta2, Pedro Freitas3, João Cruz4, Marina Rocha4, Manuela Cruz5, Teresa Fonseca1

1 CHLN – Hospital Pulido Valente – Medicina III, Portugal

2 UCSP Penha de França – ACES Lisboa Central, Portugal

3 CHLO – Hospital Santa Cruz – Cardiologia, Portugal

4 CHLN – Hospital Pulido Valente – Unidade Técnicas de Cardiologia, Portugal

5 USF Benfica Jardim – ACES Lisboa Norte, Portugal

*Corresponding author: Mariana Alves,  CHLN – Hospital Pulido Valente – Medicina III, Portugal

Received: 27 December 2019; Accepted: 03 January 2020; Published: 06 January 2020

Citation: Mariana Alves, André Rodrigues, Fabrizio Cossutta, Pedro Freitas, João Cruz, Marina Rocha, Manuela Cruz, Teresa Fonseca. Atrial Fibrillation Screening in Elderly Patients With Risk Factors for Stroke. The Value of Prolonged Cardiac Monitoring. Cardiology and Cardiovascular Medicine 4 (2020): 021-027.

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Abstract

Objective: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in the elderly and a major cause of stroke. Compared to standard care procedures, prolonged Holter electrocardiogram (ECG) monitoring might increase detection of AF. We aim to determine the prevalence of paroxysmal AF (PAF) in elderly patients with increased stroke risk and without known AF, using prolonged Holter ECG monitoring in a primary healthcare setting.

Methods: Prospective study with a community convenience sample. Inclusion criteria: age ≥ 65 years, no known AF and at least one additional risk factor for stroke according to the CHA2DS2VASc score. Heart rhythm was determined by continuous 4 day Holter monitoring. The primary endpoint was the detection of AF (lasting ≥ 30 seconds and ≥ 10 seconds).

Results: Fifty patients, mean (SD) age was 72,9 (±5.2) years, were included. Thirty-six (72%) were female. Forty patients (80%) had at least two additional risk factors for stroke. Mean duration of monitoring was 93 hours. Atrial fibrillation was detected in 7 out of 50 patients (14%). Two thirds of arrhythmias were detected in the first 24h of monitoring. An additional 4% (2 incidences) of PAF were found by prolonging cardiac monitoring to 96 hours.

Conclusions: The prevalence of undiagnosed PAF in primary health practice is high. Most cases of PAF were detected in the first 24h. Holter ECG monitoring proved effective in detecting a considerable number of events and is well-tolerated, which would allow it to be used as a screening method.

Keywords

Atrial fibrillation; Oral anticoagulation; Primary prevention; Primary health care; Screening

Atrial fibrillation articles, Oral anticoagulation articles, Primary prevention articles, Primary health care articles, Screening articles

Article Details

Background

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, with a prevalence of around 10% in the general population over 80 years [1]. AF is one of the major causes of stroke, and ischemic strokes with AF tend to be more severe compared to other ischemic strokes [2]. However, AF can be largely asymptomatic (silent), [3]  and therefore undiagnosed. Indeed, one of the first clinical signs of AF is often an ischemic stroke [4]. Oral anticoagulation therapy is effective in lowering the risk of most thromboembolic complications associated with AF [3], thereby substantially reducing stroke-related mortality and disability. Thus, there is a need to better detect silent AF, particularly in the elderly population with an increased risk of stroke.

American and European guidelines defined by consensus that an AF episode lasts longer than 30 seconds [5,6]. However short-run atrial tachyarrhythmia events have been associated with an increased risk of stroke [7,8], and since 2014, the American Heart Association guidelines have omitted how long an episode should be to be formally considered an AF [9].

Recently, the risk/benefit of AF screening has been the subject of debate [10,11]. Observational study suggest that screen-detected AF responds to treatment similarly to that detected during routine care [12]. However, the most effective screening strategy is still unclear [10].

The primary aim of this study is to determine the presence of silent AF (paroxysmal or persistent) in otherwise healthy patients older than 65 with at least one additional risk factor for stroke, using 4 day Holter monitoring. As a secondary endpoint we aim to test the tolerability of this device in the elderly, but generally healthy population.

Methods

We designed a prospective study with a convenience sample from a primary healthcare centre. Participants were enlisted after invitation by their General Practitioner (GP) for an 11 months period. Inclusion criteria were: age ≥ 65 years; absence of known AF; absence of pacemaker or cardiac resynchronization therapy (CRT); no anticoagulant medication for any other reason; at least one of the additional risk factors for stroke (based on CHA2DS2VASc score): congestive heart failure, hypertension, diabetes mellitus, previous stroke or transient ischemic attack, atherosclerotic vascular disease, female sex. These risk factors were identified by consulting the clinical process and medical history of the patients.

Heart rate and rhythm were evaluated by radial pulse examination. In case of detection of arrhythmia an ECG – rhythm strip was performed to determine the presence of AF. Patients without AF or regular heart rate by pulse palpation, underwent a prolonged 4 days Holter monitoring, the results of which were interpreted by two experienced cardiology technicians.

The presence of paroxysmal atrial fibrillation (PAF) was defined as the occurrence of at least one irregular supraventricular arrhythmia and no discernible P waves lasting for at least 30 seconds. Supraventricular arrhythmia was defined as occurrence of one or more events with a minimum of 10 seconds [6].

 The ethics committee approval was obtained, and all patients provided informed written consent prior to participation in the study.

The characterization of the studied population was performed with descriptive and inferential statistics (SPSS v21).

Results

A total of 50 patients were enrolled. Thirty-six (72%) were female and the mean (SD) age was 72,86 (±5.2). All patients had rhythmic pulse at the first visit. Mean duration of monitoring was 93 hours. Two patients only had 2 days of records (due to battery failure), and another two had 3 days of records (one due to pruritus and another due to electrodes detachment).

With regards to additional risk factors for stroke (table 1): 92 % of patients had hypertension, 24% had diabetes, 4% had a history of stroke and 2% had had a previous transient ischemic attack. We did not identify patients with previous records of congestive heart failure or atherosclerotic vascular disease. In table 1, the epidemiologic characteristics and burden of risk factors per patient are indicated. 

Among our sample, supraventricular arrhythmia lasting ≥ 10 seconds was detected in 40% (n=20) and PAF lasting ≥ 30 seconds in 14% (n=7) of the patients. Ninety-five % of supraventricular arrhythmia lasting ≥ 10 seconds was detected in the first 24 hours, while 71,4 % of PAF lasting ≥ 30 seconds was detected in the first 24 hours (figures 1 and 2).

According to the CHA2DS2VASc score, all patients with PAF ≥ 30 seconds (n=7) had indication to start anticoagulation.  Moreover, three patients were referred to the cardiology clinic due to incidental findings by echocardiogram: two patients with aortic stenosis and one with a suspected ventricular septal defect. 

Regarding tolerability, only one patient referred pruritus, which prevented the conclusion of the 4 day monitoring. Otherwise, despite referring to some irritation due to the prolonged monitoring, the device was well tolerated.

Risk factors

n (%)

Hypertension

46 (92)

Diabetes Mellitus

12 (24)

Congestive heart failure

0 (0)

Atherosclerotic vascular disease

0 (0)

Previous stroke

2 (4)

Previous transient ischemic accident

1 (2)

Female sex

36 (72)

≥ 75 years

22 (44)

Burden of additional risk factors for stroke

 

1

10 (20)

2

17 (34)

3

18 (36)

4

4 (8)

Table 1: Table. Epidemiologic characteristics and additional risk factors

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Figure 1: Cumulative incidence of supraventricular arrhythmia ≥ 10 seconds

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Figure 2: Cumulative incidence of PAF  ≥ 30 seconds

Discussion

Based on the available literature, we expected Holter monitoring lasting 96 hours to be superior to the standard 24 hours monitoring. Indeed, in our study we detected an additional two incidences (4%) of PAF when Holter monitoring was prolonged from 24 to 96 hours. This constitutes an important finding as we could then start anticoagulation on these patients. Thus, despite the small sample size, we were able to report value of prolonged Holter monitoring.

PAF detection in our study was higher compared to a related Swedish study (14 % vs 9%), which used handheld ECG for intermittent, 20 to 30 second, recordings, also on an otherwise healthy elderly population [13]. Overall, our sample seems to be “healthier”, with less prevalence of congestive heart failure or previous stroke/TIA and without known AF, and their population was slightly older (75-76 years old versus our mean age of 72.86). Thus, continuous Holter monitoring may be more effective for detecting PAF than intermittent recording in this population.

Our study presents some limitations. Firstly, the CHA2DS2VASc score was calculated by consulting medical records and therefore some comorbidities could have been underdiagnosed. This study was also planned for a pre-defined period, and during this period only 50 patients were included. This sample size confers a lower statistical power, which decreases the strength of our conclusions. However, the value of pre-screening for AF in at risk populations is supported by a previous study [13], and the results are thus important for clinical practice approach.

The main strength of our study is that it was focused on the elderly population of a primary healthcare practice with risk of stroke but without previous thromboembolic events. Therefore, our approach of prolonged Holter monitoring could improve primary prevention. In addition, the population included in this study represents a common group attending primary healthcare practice, so is readily accessible. Only four patients could not complete the 96h monitoring (8%), therefore we conclude that this device was well-tolerated.

In conclusion, we detected that asymptomatic PAF is frequent in the primary health setting, especially in the elderly population with additional stroke risk factors. Holter ECG monitoring proved effective in detecting a considerable number of events and is well-tolerated, which would allow it to be used as a screening method.

Disclosures/Financial support and sponsorship

Five authors received financial support from industries to attend medical conferences: Mariana Alves (Boehringer Ingelheim, AstraZeneca, Bayer, Bristol-Myers Squibb, Grünenthal, Tecnimede, Merck Sharp & Dohme), André Rodrigues (Bayer, Boehringer Ingelheim, Servier, Menarini, AstraZeneca, VitalAire, Pfizer), Pedro Freitas (Novartis, Bayer, Sociedade Portuguesa de Cardiologia), Manuela Cruz (Laboratórios Vitória) and Teresa Fonseca (Daiichi Sankyo, Servier, Boehringer Ingelheim, Pfizer, Bayer). Holter devices sponsored by Boehringer Ingelheim.

References

  1. Camm AJ. The Role of Continuous Monitoring in Atrial Fibrillation Management. Arrhythmia Electrophysiol Rev 3 (2014): 48-50.
  2. Lowres N, Neubeck L, Salkeld G, et al. Feasibility and cost-effectiveness of stroke prevention through community screening for atrial fibrillation using iPhone ECG in pharmacies. The SEARCH-AF study. Thromb Haemost 111 (2014): 1167-1176.
  3. Ahmad Y, Kirchhof P. Gone fishing (for silent atrial fibrillation). Circulation 127 (2013): 870-872.
  4. Brachmann J, Morillo CA, Sanna T, et al. Uncovering Atrial Fibrillation Beyond Short-Term Monitoring in Cryptogenic Stroke Patients: Three-Year Results From the Cryptogenic Stroke and Underlying Atrial Fibrillation Trial. Circ Arrhythm Electrophysiol 9 (2016): e003333.
  5. Fuster V, Ryden LE, Cannom DS, et al. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation). J Am Coll Cardiol 48 (2006): 854-906.
  6. Kirchhof P, Benussi S, Kotecha D, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur J Cardiothorac Surg 50 (2016): e1-e88.
  7. Yamada S, Lin C-Y, Chang S-L, et al. Risk of Stroke in Patients With Short-Run Atrial Tachyarrhythmia. Stroke 48 (2017): 3232-3238.
  8. Isaew A, Adderley NJ, Ryan R, Fitzmaurice D, Marshall T. The treatment of paroxysmal atrial fibrillation in UK primary care. Heart 103 (2017): 1502-1507.
  9. January CT, Wann LS, Alpert JS, et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation. 2014;130(23):2071-2104.
  10. Lown M, Moran P. Should we screen for atrial fibrillation? BMJ 364 (2019): l43.
  11. Mandrola J, Foy A. Downsides of Detecting Atrial Fibrillation in Asymptomatic Patients. Am Fam Physician 99 (2019): 354-355.
  12. Freedman B, Camm J, Calkins H, et al. Screening for Atrial Fibrillation: A Report of the AF-SCREEN International Collaboration. Circulation 135 (2017): 1851-1867.
  13. Engdahl J, Andersson L, Mirskaya M, Rosenqvist M. Stepwise screening of atrial fibrillation in a 75-year-old population: Implications for stroke prevention. Circulation 127 (2013): 930-937.

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