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Clinical Assessment of NanoFat as Treatment for Partial Rotator Cuff Tear

Author(s): Ronald B Barreto, Ricardo E R Silva Jr, Juliana M C Lira, Joao M M de A Santos, Bernard P R Barbosa, Jose F S D Lana, David Sadigursky

Despite the various available options for managing Rotator Cuff Tear, achieving definitive treatment remains a major challenge. Considering a conservative treatment failure rate of 41% and a retear rate of 21%, new therapeutic approaches are necessary. The utilization of mesenchymal stem cells has garnered increasing attention due to their capacity for tissue regeneration and reduction of local joint inflammation. The goal of this study is to evaluate the impact of NanoFat intratendineous injection on patients diagnosed with Rotator Cuff Tear. This study involved a total of 14 shoulders (7 right and 7 left) from 12 patients diagnosed with Rotator Cuff Tear, who underwent one-year follow-up after ultrasound-guided intratendineous NanoFat injection. The collection of material for injection into the affected tendon was obtained through abdominal liposuction. All patients underwent evaluations at 1 week, 1-, 3-, 6-, and 12-months post-procedure. During all follow-up visits, the UCLA, SPADI, and CMS questionnaires were administered as primary outcome measures to assess the clinical impact of the proposed intervention. Following one year of the procedure, significant improvements of 79.88% and 76% were observed in the UCLA and SPADI scores, respectively (p < 0.001). The CMS questionnaire did not exhibit a statistically significant difference in scores at the conclusion of the evaluation. Regarding sociodemographic data, the mean age observed was 50 years, the mean BMI was 28.1kg/m2, the mean weight was 75.1kg, and mean height was 1.63m. This study has provided evidence of functional improvement and pain reduction in patients with Rotator Cuff Tear undergoing NanoFat treatment.

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Impact Factor: * 4.3

CiteScore: 2.9

Acceptance Rate: 73.64%

Time to first decision: 10.4 days

Time from article received to acceptance: 2-3 weeks

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