Relationship between Glutathione S Transferase P1 and Toll like Receptor 2 Polymorphisms and Infections in Sickle Cell Anemia

Author(s): Géssyka Jerônimo Silva, Romério Alencar de Oliveira Filho, Igor de Farias Domingos, Rodrigo Marcionilo de Santana, Thais Helena Chaves Batista, Aderson da Silva Araújo, Marcos André Cavalcanti Bezerra, José Luiz de Lima Filho, Danyelly Bruneska Gondim Martins, Rosângela Ferreira Frade de Araújo

Infections are the most common complications in individuals with sickle cell anemia. The splenomegaly of these individuals results from erythrocytes being sequestrated, resulting in organ atrophy and fibrosis. However, even before splenomegaly, phagocytic capacity and antibody production are affected as a result of splenic activity, leading to functional asplenia and increased susceptibility to infections. The reactive oxygen species (ROS) produced by phagocytes when activated by pathogenic microorganisms act as bactericides. On the other hand, oxidative damage to erythroid cells also plays a crucial role in hemolysis. We investigated the influence of GSTP1 and TLR2 genetic polymorphisms on susceptibility to infections in 278 patients with sickle cell anemia. These proteins offer protection against oxidative damage and play a key role in host defense against infection, respectively. However, our results do not support any major role of GSTP1 or TLR2 polymorphisms in susceptibility to infection in subjects with sickle cell anemia.