Abstracting and Indexing

  • Google Scholar
  • CrossRef
  • WorldCat
  • ResearchGate
  • Academic Keys
  • DRJI
  • Microsoft Academic
  • Academia.edu
  • OpenAIRE

Serological and PCR evidence of Infection in 105 Patients with SPPT

Author(s): Alexis Lacout, Marie Mas, Michel Franck, Véronique Perronne, Julie Pajaud, Pierre Yves Marcy, Christian Perronne

Introduction: The main aim of this study is to determine the nature of the exposure of patients presenting with polymorphic signs and symptoms to the parasite Babesia, through the study of serology. The secondary aim is to report the different serological or PCR results observed in these patients.

Material and methods: The following serologies were performed in all patients looking for: Babesia divergens, Borrelia, Bartonella, Coxiella burnetii, Anaplasma phagocytophilum. The following PCRs were performed looking for: Borrelia spp, Babesia spp, Bartonella (Bartonella spp, B. quintana, B. Henselae,) Coxiella spp, Anaplasma spp, Ehrlichia spp, Rickettsia spp, most often on several matrices (venous blood, capillary blood, urine and saliva).

Results: In this study, 105 patients were included, 62 females and 43 males, sex ratio F/M was 62/43 = 1.44; mean age was 45.5 year old (range; 5 years, 79 years old). Of the 105 serologies for B. divergens, 41 % were found to be positive. Of the 104 serologies for Borrelia, 19.2 % were found to be positive. Of the 104 serologies for Borrelia, 19.2 % were found to be positive. Of the 95 serologies for Anaplasma, 27,3 % were found to be positive. Borrelia spp, Babesia spp, Bartonella spp, Coxiella spp, Anaplasma spp, Ehrlichia spp, Rickettsia spp were found by using rtPCR.

Conclusion: Our study has shown that patients with SPPT/PTLDS, a syndrome close to fibromyalgia, could harbor several tick borne microorganisms. Microbiologic analyses should thus not be merely limited to Borrelia's research alone.

    Editor In Chief

    Masashi Emoto

  • Professor of Laboratory of Immunology
    Department of Laboratory Sciences
    Gunma University Graduate School of Health Sciences
    Gunma, Japan

© 2016-2021, Copyrights Fortune Journals. All Rights Reserved!