Klebsiella Pneumoniae Producing Extended-Spectrum Β-Lactamases seen in the Laboratory of the University Hospital of Befelatanana Antananarivo Madagascar

Author(s): Fidiniaina Mamy Randriatsarafara, Zafindrasoa Domoina Rakotovao-Ravahatra, Njaramahery Williame Andriamampandry, Andriamiadana Luc Rakotovao

Background: Klebsiella pneumoniae producing extended-spectrum β-lactamases is an important nosocomial pathogen. The objective of this study is to describe the factors associated with Klebsiella pneumoniae producing extended-spectrum β-lactamases infections.

Methods: It is a prospective study of 113 isolates of K. pneumonia for a period of 18 months from January 2020 to June 2021 in the laboratory of the University Hospitals of Befelatanana.

Results: Among 113 isolates of Klebsiella pneu-moniae, 78 (69%) were represented by Klebsiella pneumoniae producing extended-spectrum β-lactamases. Men (79.3%;p=0.01), subjects less than 20 years (85.2%; p=0.001), and with infectious syndrome (77.9%; p= 0.002) were the most affected by Klebsiella pneumoniae producing extended-spectrum β-lactamases infections. Among these subjects, newborns hospitalized in intensive care units (75%;p=0.01) were the most affected by these infections. Moreover, these infections were more common in summer (69.1%; p=10-2).

Conclusion: Strict hygiene measures are very important in hospital wards to fight against these Klebsiella pneumoniae producing extended-spectrum β-lactamases, especially in neonatal intensive care units.