Pathophysiology of Hodgkin’s Lymphoma and Role of Immune System

Author(s): Kalsoom Abidi Malik, Zunaira Hameed, Marvah Qiass

Hodgkin’s lymphoma is a disease which originates from white blood cells that are known as lymphocytes. It is primarily mutation of B lymphocytes, it has a special ability to cause deficiency of immune system and also give immune escape process to avoid from self-destruction. In this article we will discuss Hodgkin’s disease and its relation with immune system and also evaluate the function of regulatory B cells in Hodgkin’s disease, origin of HRS and HP cells, role of stains and down regulation of B cells. Epstein-Barr disease (EBV) is the vitally powerful expert that dependably has been connected with HD, EBV-encoded RNA is recognized in the HRS cells more than in 40% of cases.