Adenomyoma of Ampulla: A Report of Three Cases of a Rare Entity

Author(s): Maryam Cheddadi,Rihane El Mohtarim, Samia Sassi, Sabrine Derqaoui, Fouad zouaidia, Kaoutar Znati, Zakia el bernoussi, Ahmed Jahid

Adenomyoma is an uncommon, benign lesion with reactive and hamartomatous features resembling a tumor. While it can manifest anywhere along the gastrointestinal tract, including the gallbladder, stomach, duodenum, and jejunum, its occurrence in the extrahepatic bile duct and ampulla of Vater (AOV) is exceedingly rare. Adenomyomas affecting the Vaterian system (ampulla and common bile duct) carry significant clinical implications, as most of these lesions manifest with obstructive biliary tract symptoms and exhibit characteristics similar to malignancies. Histologically, it can be easily confused with well-differentiated adenocarcinoma. Hence, meticulous histological assessment is imperative to confirm the diagnosis definitively. Here, we present the pathological observations from three cases of ampullary adenomyoma, highlighting the rarity of this condition and the diagnostic challenges it presents.