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Hair Growth and Restoration by Transcriptional Control of Tissue Regeneration in Cancer Recovery Process by Huaier

Author(s): Manami Tanaka, Tomoo Tanaka, Xiaolong Zhu, Fei Teng, Hong Lin, Zhu Luo, Ying Pan, Sotaro Sadahiro, Toshiyuki Suzuki, Yuji Maeda, Ding Wei and Zhengxin Lu

Objectives: In the process of caner recovery, Huaier simultaneously promotes significant hair growth and restoration as a typical evidence of its efficacy on induced tissue regeneration and repair function. As a series of our clinical research, the molecular basis of hair growth was investigated.

Methods: The blood samples from volunteer cancer patients and normal healthy controls were collected and produced by next generation sequencing, and searched for significant alterations in genetic level specifically focused on all the signaling networks related to hair growth and restoration, and also related to Huaier effects on tissue regeneration and repair. The results were compared between cancer patients with or without conventional chemotherapy, and normal control group with or without Huaier treatment.

Results: We identified Hair growth after conventional chemotherapy was a first and significant observation, and that in dose-dependent manner. The molecular basis of hair growth was identified as the activation of Hedgehog signaling pathway, which initiates systematic tissue repair not only in cancer lesions together with the cure of skin problems and perturbed inter/ intra neural signal transfer. Huaier efficacy on the activation of Hedgehog signaling pathway was followed by the subsequent inhibition at 3-6 months interval. This inhibitory effects seemed to contribute to the prevention of possible complications in the process of cancer recovery, such as recurrence and metastasis. Small nuclear RNA analysis revealed that the regulation of tissue regeneration, including hair growth were based on the miRNA-mediated transcriptional control of the pluripotency of stem cells.

Conclusion: The present study thus provides a simple and clear proof of Huaier effects on tissue regeneration, easily observed as hair growth and restoration. Periodical regulation in both ways to activate and inhibit the Hedgehog signaling pathway function is required. The designated regulation of SMO (smoothhead) was not specifically associated with the alterations in the Hedgehog signaling pathway in the process of cancer recovery with Huaier treatment. Cancer recovery process requires both anti-cancer effects cancer cell-specific cell death and subsequent tissue regeneration. Huaier provides valuable efficacy as the Hedgehog signal regulator, with no toxicity or side effects. The present study also proved that Huaier over 20g per day could accelerate the cure of skin problems, and also control on blood pressure down to the normal level.

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