Challenges in Hematologic Care: A Case Report of Sickle Cell Disease and Multiple Myeloma Concurrence

Author(s): Supriya Peshin, FNU Warsha, Tamanna Taznin, Shagun Singh, FNU Vineesha, Marissa G Vito Cruz

This case report details the complex medical journey of a 69-year-old African American female with a multifaceted history, including sickle cell anemia with hemoglobin C disease, hypothyroidism, hypercholesteremia, severe obesity, autoimmune hemolytic anemia, and multiple myeloma. Initially referred for evaluation of asymptomatic pancytopenia, the patient was later diagnosed with IgG kappa monoclonal paraproteinemia, consistent with multiple myeloma, ISS stage II. Throughout her treatment, she underwent several cycles of chemotherapy, facing multiple complications, such as recurrent sickle cell crises, significant anemia, and elevated liver enzymes. These complications necessitated careful management and adjustments to her therapeutic regimen, reflecting the intricate interplay between her coexisting conditions. Despite these challenges, the patient exhibited partial improvement, underscoring the need for a tailored and multidisciplinary approach to managing such complex cases. This report highlights the diagnostic and therapeutic difficulties in treating patients with concurrent sickle cell disease and multiple myeloma, emphasizing the importance of personalized care to optimize outcomes.