Comparison of Serum Vitamin D level in Women with and without Uterine Fibroid

Author(s): Dr. Sabiha Islam, Prof. Dr. Tripti Rani Das, Farah Noor, Dr. Jinat Fatema, Dr. Iffat Rahman, Dr. Shah Noor Sharmin, Dr. Bidisha Chakma, Dr. Tanzina Iveen Chowdhury

Background: Uterine fibroids are common, affecting 70-80% of reproductive-aged women universal. They are more regular in African and South Asian women (Stewart et al, 2017). Vitamin D deficiency is greatly prevalent 60-90% in Bangladesh and the Indian subcontinent (Siddiqi et al, 2021; Chowdhury et al, 2018).

Aim: To find out the association of serum vitamin D levels among women with and without uterine fibroid.

Methods: A case-control study was conducted at the Bangladesh Medical University (BMU), Dhaka, from September 2021 to August 2022, involving 128 women aged 18-49 years. Among them 64 women with ultrasonographically proven uterine fibroids were associated to 64 age-matched controls without fibroids. Serum vitamin D levels were considered, and significant socio-demographic and lifestyle data were gathered. Statistical analysis was performed using Chi-square and independent t-tests with a significant level of p<0.05 OR indicates the association between the case and control group.

Results: Among the participants, 84.4% were identified with uterine fibroids. A significant proportionality 88.3% had inadequate vitamin D levels (20–30 ng/mL), with only 11.7% proving sufficient levels (>30 ng/mL). The prevalence of vitamin D deficiency was significantly greater in women with fibroids associated to individuals without (p=0.004), with an odds ratio (OR) of 1.886. In addition, the mean vitamin D level varied significantly among the fibroid and non-fibroid groups (p=0.043).

Conclusion: Women with uterine fibroids had significantly reduce serum vitamin D levels associated to persons devoid of fibroids. This advises that vitamin D deficiency may be related with fibroid growth, emphasizing the significance of vitamin D evaluation in clinical observe.