Specific Composite Biomarker Profiles for β-Amyloid Accumulation in Peripheral Blood in Healthy Subjects Relevant to Biological Factors: Comparison with Patients with Dementia

Author(s): Kouji Satoh, Maremi Sato-Ueshima, Hiroyo Kagami-Katsuyama, Masakazu Nakamura, Akihiko Ogata, Mari Maeda-Yamamoto, Jun Nishihira

Measurement of amyloid concentration in blood using time-of-flight mass spectrometry was developed, and the combined normalized score of amyloid precursor proteins (composite biomarker: CM) in plasma was found to be related to the accumulation of β-amyloid (Aβ) in the brain. Therefore, we measured the CM value in healthy subjects aged 30-79 years and investigated the association between the CM value and clinical characteristics using multiple regression and decision tree analyses. The results indicated that the CM value was associated with age, sex, ApoE genotype, blood glucose, and Mg in healthy subjects. Factors affecting CM values differed by age. The CM values of patients with central nervous system disorders were higher than those of the healthy subjects. Moreover, the relationship between CM and Mg concentrations differed between the patients and healthy subjects. These results suggest that the CM value can be used as a biomarker for the onset of dementia, including Alzheimer’s disease. The combination of CM values and blood component results may allow for more accurate diagnosis.