The Constrained Disorder Principle Defines Mitochondrial Variability and Provides A Platform for A Novel Mechanism for Improved Functionality of Complex Systems

Author(s): Yaron Ilan

Traditionally viewed as static structures, new advancements in molecular biology and imaging have revealed the dynamic nature of mitochondria. Exploring the functional implications of mitochondrial DNA variability provides insight into the mechanisms underlying physiological processes and potential associations with metabolic disorders. The Constrained Disorder Principle (CDP) is a fundamental law that applies to all living and non-living systems in nature. The principle describes every system in terms of its inherent variability, which is bounded by dynamic boundaries, allowing it to adapt to environmental changes. According to the CDP, inherent variability is necessary for complex systems to function correctly. This paper aims to explain how the CDP defines mitochondrial variability. The CDP explains how mitochondria adapt to the demands and pressures placed on them by the cellular environment. Evidence linking mitochondrial variability to various diseases demonstrates the importance of CDP-defined dynamic boundaries of variability in complex systems. An artificial intelligence platform based on CDP is presented as a potential tool for diagnosing and treating mitochondrial diseases, which could be used to improve system functionality and overcome disease states.