Mean Platelet Volume/ Platelet Count Ratio in male and female patients with Iron Deficiency Anemia

Author(s): Mangyung Kandangwa, Damandeep Kaur Dhillon, Johnson Igwe, P Ramesh Babu, Suma Kaza

Mean platelet volume (MPV) and platelet counts (PC), are sensitive indicators of inflammation and various pathologies. The MPV/PC ratio (MPR) has emerged as a potentially more sensitive and has been applied in studying iron deficiency anemia (IDA). However, hematological parameters tend to be different in men and women. This study explores the relationship between sex and platelet parameters in the context of IDA. The hematological samples were analyzed on HORIBA 5 part haematology analyser. IDA was classified as Hb< 13.0 g/dL and MCV<76 fl for male and Hb< 12.0 g/dL and MCV< 76 fl for female. Patient were classified as non-IDA when the hematological parameter did not fit for IDA. Samples from healthy population was control. Data analysis was performed using Microsoft Excel and GraphPad Prism 7. Statistical analysis was done with Unpaired t-test with Welch’s correction and Brown-Forsythe and Welch ANOVA test. Our result showed MPR had significant difference in male IDA group. Further analysis showed that, in control, females had higher PC than in male, with no significant difference in MPV. In IDA, the PC increased in both male and females, but MPVdecreased significantly only in males.