Thyroid Stimulating Hormone Correlation with Analysis of Fasting Bile and Stone in Gallstone Diseases

Author(s): Tippisetty Vineet, Yogesh Kumar

Background and Aims

To correlate serum TSH (Thyroid stimulating hormone) levels with fasting bile cholesterol and TSH levels and with type of stone in gallstone disease.

Materials and Methods

A cross sectional study was conducted from October 2016 to August 2018 in the hospitals attached with Kasturba medical college, Mangalore. A detailed pro forma was developed to record information regarding patients hospital details, age, sex, routine blood investigations, special investigations and imaging study.

Results

Study conducted in 48 patients (22 male and 26 female) with diagnosed gallstone disease. A 23% of patients have elevated serum TSH who never had history of thyroid disease. Though maximum number of those with elevated TSH were in the 31-40 years category (5 out of 20), the higher proportion was seen in the 41-50 years age group (42.9%, that is; 3 out of total 7). A significant 33% of patients had elevated fasting bile TSH levels with female preponderance, even higher than the number of those with elevated serum TSH level. The number of patients with elevated bile TSH fell in the 31-40 years age group (8 out of 20), the higher proportion was seen in the 41-50 years age group (57.1%, that is, 4 out of 7).

Conclusion

A statistically significant independent relationship between serum TSH and fasting bile TSH were established with female patients of gallstone disease. Subclinical hypothyroidism indeed plays a significant role in cholesterol cholelithiasis, especially in women.