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Study of Correlation between Serum Amylase and Serum Lipase level with Percentage of Necrosis on CECT in Acute Necrotising Pancreatitis

Author(s): Shifa A Kalokhe, Lisha Suraj, Shrutik Devdikar

Background

Acute pancreatitis (AP) is a common inflammatory disease of pancreas, mainly characterized by local inflammation of the pancreas due to activation of pancreatic enzymes and increase in serum amylase and lipase levels. As studies suggests 20% of patients with acute pancreatitis develop necrotizing pancreatitis. The aim of our study was to determine whether patients with necrotizing pancreatitis had any significant correlation with Serum Amylase and Lipase Level and if it helps in Early predictability of percentage of Necrosis.

Aim

Methods

To determine correlation between Serum Amylase and Serum Lipase Level with Percentage of necrosis on CECT in patients with Acute Necrotising Pancreatitis. We will be assessing all patients presenting to Institution and diagnosed as a case of Acute Necrotizing Pancreatitis. All Routine Investigation along with Amylase and Lipase done for the Patient, CECT of the Patients were done after 72 hrs of onset of attack. Comparison was done between the relation of Serum Amylase-Lipase level and the percentage of Pancreatic Necrosis mentioned on CECT.

Results

In this retrospective study done from January 2021 to January 2022, 40 cases of Acute Necrotising Pancreatitis were evaluated, it was found that there was no significant correlation between Serum Amylase and Lipase level and the percentage of Necrosis on CECT abdomen.

Conclusion

It was found that level of serum amylase and serum lipase on admission is not a good predictor to assess the percentage of necrosis of pancreas on CECT abdomen. The level of serum amylase and lipase depend on the time of onset of symptoms but the patient's presentation to hospital is variable which can be a cause for error.

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