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Application of BloodSTOP iX Wound Heal Nanocellulose Matrix for Burn Wound Care

Author(s): Shiying Ju, Kun Wang, Liang Qiao, Yingde Xu, Amanda Reed-Maldonado, Lia Banie, Dongyi Peng, Tianshu Liu, Guifang Wang, Zhongcheng Xin, Guiting Lin

Objectives: Better dressings are needed for both receiver and donor sites in clinical management of burn wounds. Current study aims to check the efficacy and safety of BloodSTOP iX Wound Heal Nanocellulose Matrix (BSM) in managing burn wound.

Materials and methods: Characterization of BloodSTOP iX Nanocellulose Matrix was assayed with scanning electron microscope (SEM) and Fourier Transform Infrared Spectroscopy (FT-IR). For the preclinical study, two burn injury animal models were established: a contusion model and partial-thickness burn model. A total of 12 rabbits (male/female; 2.0-2.5 kg) were used in this initial experiment. Assessments were made at two time points: 1 week and 2 weeks post-injury. Six rabbits underwent skin contusion and six partial-thickness skin burn. At 1 week and two weeks post-injury, gross pathologic and histologic observations of changes and scarring were conducted. For clinical trial, during September 2015 to September 2016, a total 46 patients from two medical centers were enrolled in this study, including control group 16 cases and BSM 30 case. Each group has been sub-grouped into skin donor site and transplanted site. At 7, 14 and 20 days post treatment, clinical outcome were assayed.

Results: The microstructure of Nanocellulose and nano-structure of BloodSTOP iX Wound Heal Nanocellulose Matrix was confirmed. Preclinical results demonstrated that BSM promoted the burn wound healing in both animal models. In the clinical experiment, BSM decreased recurrence of bleeding post application and burning/pain feeling, while an anti-infection effect was also noted. More strikingly, BSM promoted skin epithelialization and improved scar tissue. Those effects were observed in both donor and receiver sites.

Conclusion: BloodSTOP iX Wound Heal Nanocellulose Matrix (BSM) is safe and effective in burn wound c

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