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Acral Syringotropic Melanoma in situ with Eccrine Duct Hyperplasia

Article Information

Mitsuhiro Tachibana1*, Seiya Kitano2, Ayako Mikura3, Masakazu Fujimoto4, Kuniaki Ohara5, Miki Izumi6, Yutaka Tsutsumi1,7

1Department of Diagnostic Pathology, Shimada Municipal Hospital, Shimada, Shizuoka, Japan

2Department of Dermatology, Shimada Municipal Hospital, Shimada, Shizuoka, Japan

3Departmenty of Plastic Surgery, Shimada Municipal Hospital, Shimada, Shizuoka, Japan

4Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Kyoto, Japan

5Dermatology Clinic, Akasaka Toranomon Clinic, Minato-ku, Tokyo, Japan

6Department of Medical Education, Showa University, Shinagawa-ku, Tokyo, Japan

7Diagnostic Pathology Clinic, Pathos Tsutsumi, Inazawa, Aichi, Japan

*Corresponding Author: Dr. Mitsuhiro Tachibana, Department of Diagnostic Pathology, Shimada Municipal Hospital, 1200-5 Noda, Shimada, Shizuoka 427-8502, Japan

Received: 12 March 2021; Accepted: 22 March 2021; Published: 31 March 2021

Citation: Mitsuhiro Tachibana, Seiya Kitano, Ayako Mikura, Masakazu Fujimoto, Kuniaki Ohara, Miki Izumi, Yutaka Tsutsumi. Acral Syringotropic Melanoma in situ with Eccrine Duct Hyperplasia. Archives of Clinical and Medical Case Reports 5 (2021): 355-360.

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Acral syringotropic melanoma with eccrine duct hyperplasia (ASMEDH) is rare. We describe ASMEDH arising in the right sole of a Japanese woman aged 80’s. On a 15 x 10 mm-sized, irregular-shaped pigmented macule, the dermoscopy indicated pararrel ridges. The lesion was removed surgically. No nodal swelling was noted. Microscopically, the pigmented melanoma cells were distributed not only in the basal epidermis but also in the cutaneous sweat gland duct. The melanoma cells were positive for HMB45, melan A, S-100 protein, bcl-2, vimentin, CD5 and SOX10, but negative for cytokeratins (CKs) and adipophilin. Ki-67 labeling was around 10%. In the dermis, basal cells immunoreactive for CK 34βE12, CK5/6 and p40 surrounded the intraductally spreading melanoma cells and ductal lumina were frequently located in the center. Invasive growth was absent. The surgical margins were negative. The patient did not receive adjuvant chemotherapy, and she is doing well eight months after surgery. Our final diagnosis was ASMEDH, melanoma in situ, the third case in the world.


Malignant melanoma in situ; Syringotropism; Eccrine duct hyperplasia

Malignant melanoma in situ articles; Syringotropism articles; Eccrine duct hyperplasia articles

Article Details

1. Introduction

Malignant melanomas on the volar skin (the glabrous skin of palms and soles) are most often encountered on the foot, especially the heel being the most common site. In the majority of cases, the melanomas have a distinct lentiginous pattern of growth reminiscent of a lentigo maligna pattern [1]. The average age of the patients of acral melanoma is between 60 and 70. The characteristic dermoscopic finding of acral melanoma is termed as the parallel ridge pattern [1]. Microscopically, the most common form of melanoma on the volar skin belongs to acral lentiginous melanoma [2]. Only two cases have been reported as acral syringotropic melanoma with florid eccrine duct hyperplasia [3]. Herein, we report a rare case of acral melanoma in situ arising on the sole in a Japanese female patient aged 80’s, showing a prominent pattern of syringotropism and eccrine duct hyperplasia.

1. Case Presentation

An 80’s-year-old Japanese woman fell down in her living room. She was admitted to Shimada Municipal Hospital, Shimada, Shizuoka, Japan, and treated with right femoral head replacement for right femoral neck fracture. She had a medical history of hypertension, diabetes mellitus, hyperlipidemia, and Alzheimer’s dementia, but without any life, familial, social and environmental histories. During surgery, the orthopedic surgeon noticed a melanotic lesion of her right sole. On a 15 × 10 mm-sized, irregular-shaped pigmented macule (Figure 1a), the dermoscopy indicated pararrel ridges (Figure 1b). The lesion was later excised surgically. The patient complained of no symptoms related to the skin lesion. No nodal swelling was noted. Microscopically, the pigmented melanoma cells were distributed not only in the basal epidermis but also in the cutaneous sweat gland duct (Figure 2a, b). The nucleoli were inconspicuous. In the dermis, basal cells immunoreactive for cytokeratin (CK) 34bE12, CK5/6 (Figure 2c) and p40 surrounded the intraductal melanoma cells and ductal lumina were often recognized in the center of the involved sweat gland. No stromal invasion was revealed by immunostaining for laminin (data not shown). The surgical margins were negative. The melanoma cells were immunoreactive for HMB45, melan A (Figure 2d), S-100 protein, bcl-2, vimentin, CD5 (Figure 2e), SOX10 (Figure 2f) and CD117 (c-kit), but negative for CKs, BRAFV600E and adipophilin (Figure 2g). Ki-67 labeling was around 10%. Our final diagnosis was ASMEDH, melanoma in situ, pTis cN0 cM0: pStage 0. The patient did not receive adjuvant chemotherapy, and she remained well without recurrence eight months after the treatment.


Figure 1: Macroscopic and dermatoscopic images of the asymptomatic melanocytic lesion on the right sole. a) a 15x10 mm-sized irregular-shaped pigmented lesion is seen. b) Dermatoscopy illustrates the pararrel ridge (yellow arrows). bar=5 mm.


Figure 2: Microscopic findings. The pigmented melanoma cells were distributed not only in the basal epidermis but also along the cutaneous sweat gland duct (a, b). In the dermis, basal cells are immunoreactive for CK5/6 (c), and the melanoma cells are positive for melanA (d), CD5 (e) and SOX10 (f), but negative for adipophilin (g).

2. Discussion

We report herein a case of ASMEDH on the sole of right foot. The acral lentiginous melanoma in situ may proliferate along the eccrine duct [4]. To the best of our knowledge, only two cases of ASMEDH have been reported by Kubba, et al. 2017 [3]. An increase in the density of eccrine glands is described in palmar and plantar areas. In ASMEDH, significant increase of the gland is seen in the area with the syringotropic tumor spread, and the hyperplastic sweat glands are not distributed in the area adjacent to the tumor. These findings suggest a syringoma-like hyperplasia of the eccrine glands in reaction to the tumor growth. Eccrine duct hyperplasia, or syringofibroadenoma-like change, usually occurs as a reactive process: it has been described in association with a “hamartomatous” nasal glioma and two ASMEDHs [3, 5]. A recent report has indicated that the niche of the sweat gland maintains melanocyte-melanoma precursors, and it thus explains the preferential distribution of early melanoma cells in the sweat gland of human acral skin [6].

Significant prognostic factors of the malignant melanoma include adipophilin expression [7], CD5 expression [8], pT factor, pathological staging, mitotic activity and the association of conspicuous nucleoli. In the current case, low-adipophilin expression, low-pathological stage (pTis), low-mitotic count and inconspicuous nucleoli, except for high-CD5 expression, suggest an indolent clinical behavior.

3. Conclusion

The current report describes the third case of ASMEDH. In order to reach the correct histopathological diagnosis of this rare type of in situ malignancy, careful clinicopathological evaluations, including immunostaining with multiple antibodies, are requested. A further study pursuing the mechanism of syringotropism in ASMEDH should be conducted.

Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.


This case was presented at the 110th Annual Meeting of the Japanese Society of Pathology at Tokyo, Japan, 2021.

Patient consent statement

All the procedures were in accordance with the ethical standards of the responsible institutional committee on human experimentation and with the Helsinki Declaration of 1964 and later versions. The patient’s daughter gave a written informed consent to publication as a case report.


We cordially thank Naoki Ooishi, M.T., Department of Diagnostic Pathology, Shimada Municipal Hospital, for his excellent technical assistance and secretarial help.

We also deeply acknowledge Toshiaki Manabe, M.D., Sakai-machi Oike Diagnostic Pathology Clinic, Kyoto, Kyoto, Japan, for his advice and suggestions for the differential diagnosis of the present lesion. There were no funding sources for reporting the present case.

Conflict of Interest

The authors declare that there is no conflict of interests regarding the publication of the present case.

Authors’ Contributions

Each author has sufficiently participated in the work to take public responsibility for appropriate portions of the content. MT performed histopathological diagnosis of the resected sample, analyzed the data, drafted the figure, and made a major contribution to writing the manuscript. SK made the clinical diagnosis as malignant melanoma by analyzing with a dermatoscope. AM performed clinical evaluations, surgical treatment, and clinical follow-up. MF, MI and KO provided valuable advice and suggestions as the histopathologic consultant. YT analyzed histopathological features and brushed the manuscript up. All authors agreed with the content of the manuscript submitted for publication.


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